In addition to developing new ways to treat heart rhythm disorders with catheters inside the body, Dr. Cuculich leads a team of investigators who are pioneering an entirely noninvasive way to target and treat abnormal heart rhythms. This process uses focused radiation to the abnormal scar areas of the heart, in a similar way to treating cancer.

First report of this collaborative work was published in the New England Journal of Medicine, and results from the first prospective trial won the James T. Willerson Award for Best Paper in Clinical Science in Circulation in 2019. Dr. Cuculich is the co-Director of the Center for Noninvasive Cardiac Radioablation (CNCR, pronounced conquer ) and is widely considered a world leader in the field of noninvasive ablation.